Pathophysiology of Parkinson’s Disease

Our primary interest is to understand the molecular mechanisms that lead to Parkinson’s disease (PD). We investigate how key PD proteins aggregate in neurons and promote neurodegeneration. Our broad approach covers the main aspects of the disease, from aggregation of proteins to mitochondrial homeostasis. We also search for proteins and compounds that can modulate their pathological accumulation and toxicity, and that may be used as future therapeutics to alleviate the disease progression.


Check our new alternative theory for the pathophysiology of Parkinson’s in TRENDS IN NEUROSCIENCES we coined “The Threshold Theory”


We are looking for new students to study proteins involved in Parkinson’s Disease.

Just come to the lab to hear about our work!






Lewy Bodies in the substantia nigra of Parkinson’s patients exhibit SUMO1 immunoreactivity and accumulation of SUMOylated alpha-synuclein. From Rott et al, PNAS, 2017


We are at the Department of Biochemistry,

B. Rappaport Faculty of Medicine, Technion